Design of spray dried ternary solid dispersions comprising itraconazole, soluplus and HPMCP: Effect of constituent compositions

Int J Pharm. 2017 Mar 15;519(1-2):365-372. doi: 10.1016/j.ijpharm.2017.01.043. Epub 2017 Jan 25.


A range of 17 ternary formulations of itraconazole (ITZ), HPMCP and Soluplus have been manufactured using spray drying. These amorphous solid dispersions (ASDs) were very stable against crystallisation and ITZ was found to be amorphous in all formulations after one year at 40°C/75% RH. A number of solid state analytical techniques including PXRD, DSC, small angle X-ray scattering, FTIR and solid state NMR were used to characterise the physicochemical properties of the ASDs following processing and storage and to assess any interactions between components. Microtrac laser scattering analysis revealed a relationship between polymer levels and particle size distribution (PSD). Dissolution studies indicated that higher Soluplus content in the formulation resulted in higher concentrations of ITZ in acidic media.

Keywords: Amorphous; HPMCP; Itraconazole; Soluplus; Spray drying; Ternary.

MeSH terms

  • Calorimetry, Differential Scanning / methods
  • Chemistry, Pharmaceutical / methods
  • Crystallization / methods
  • Drug Compounding / methods
  • Excipients / chemistry
  • Itraconazole / chemistry*
  • Particle Size
  • Polyethylene Glycols / chemistry*
  • Polymers / chemistry
  • Polyvinyls / chemistry*
  • Solubility
  • X-Ray Diffraction / methods


  • Excipients
  • Polymers
  • Polyvinyls
  • polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer
  • Itraconazole
  • Polyethylene Glycols