Rab10 Disruption Results in Delayed OPC Maturation

Cell Mol Neurobiol. 2017 Oct;37(7):1303-1310. doi: 10.1007/s10571-017-0465-5. Epub 2017 Jan 28.

Abstract

Oligodendrocyte precursor cell (OPC) maturation requires membrane addition for myelin sheath formation. Since the Rab system has been shown to contribute to membrane addition in other cell types, in this study, we explored the role of Rab in OPC maturation. SiRNA and shRNA techniques and conditional knockout mice provided in vitro and in vivo evidence that Rab10 is involved in OPC maturation and may affect myelination during OPC development.

Keywords: MBP; Maturation; Membrane addition; OPC; Rab10.

MeSH terms

  • Animals
  • Animals, Newborn
  • Cells, Cultured
  • Mice
  • Mice, Knockout
  • Mice, Transgenic
  • Oligodendrocyte Precursor Cells / pathology*
  • Oligodendroglia / physiology*
  • Rats
  • Rats, Sprague-Dawley
  • rab GTP-Binding Proteins / deficiency*
  • rab GTP-Binding Proteins / genetics

Substances

  • Rab10 protein, mouse
  • rab GTP-Binding Proteins