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. 2017:2017:3845067.
doi: 10.1155/2017/3845067. Epub 2017 Jan 4.

Early Diagnosis of Helicobacter pylori Infection in Vietnamese Patients with Acute Peptic Ulcer Bleeding: A Prospective Study

Duc Trong Quach  1 , Mai Ngoc Luu  1 , Toru Hiyama  2 , Thuy-HuongThi To  3 , Quy Nhuan Bui  3 , Tuan Anh Tran  3 , Binh Duy Tran  3 , Minh-Cong Hong Vo  4 , Shinji Tanaka  5 , Naomi Uemura  6
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Free PMC article

Early Diagnosis of Helicobacter pylori Infection in Vietnamese Patients with Acute Peptic Ulcer Bleeding: A Prospective Study

Duc Trong Quach et al. Gastroenterol Res Pract. 2017.
Free PMC article

Abstract

Aims. To investigate H. pylori infection rate and evaluate a combined set of tests for H. pylori diagnosis in Vietnamese patients with acute peptic ulcer bleeding (PUD). Methods. Consecutive patients with acute PUB were enrolled prospectively. Rapid urease test (RUT) with 3 biopsies was carried out randomly. Patients without RUT or with negative RUT received urea breath test (UBT) and serological and urinary H. pylori antibody tests. H. pylori was considered positive if RUT or any noninvasive test was positive. Patients were divided into group A (RUT plus noninvasive tests) and group B (only noninvasive tests). Results. The overall H. pylori infection rate was 94.2% (161/171). Groups A and B had no differences in demographic characteristics, bleeding severity, endoscopic findings, and proton pump inhibitor use. H. pylori-positive rate in group A was significantly higher than that in group B (98.2% versus 86.7%, p = 0.004). The positive rate of RUT was similar at each biopsy site but significantly increased if RUT results from 2 or 3 sites were combined (p < 0.05). Conclusions. H. pylori infection rate in Vietnamese patients with acute PUB is high. RUT is an excellent test if at least 2 biopsies are taken.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Figure 1
Figure 1
H. pylori testing in Vietnamese patients with acute peptic ulcer bleeding.
Figure 2
Figure 2
RUT results from single specimen versus combined specimens from two biopsy sites.
See this image and copyright information in PMC

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    Quach DT, Mai BH, Tran MK, Dao LV, Tran HV, Vu KT, Vu KV, Pham HT, Bui HH, Ho DD, Trinh DT, Nguyen VT, Duong TH, Tran TT, Nguyen HT, Nguyen TT, Nguyen TD, Nguyen LC, Dao HV, Thai KD, Phan NT, Le LT, Vo CH, Ho PT, Nguyen TL, Le QD, Le NV, Phan HQ, Nguyen BC, Tran TT, Tran TV, Ta L. Quach DT, et al. Front Med (Lausanne). 2023 Jan 12;9:1065045. doi: 10.3389/fmed.2022.1065045. eCollection 2022. Front Med (Lausanne). 2023. PMID: 36714104 Free PMC article. Review.

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