SUMO and the robustness of cancer

Nat Rev Cancer. 2017 Mar;17(3):184-197. doi: 10.1038/nrc.2016.143. Epub 2017 Jan 30.


Post-translational protein modification by small ubiquitin-like modifier (SUMO), termed sumoylation, is an important mechanism in cellular responses to stress and one that appears to be upregulated in many cancers. Here, we examine the role of sumoylation in tumorigenesis as a possibly necessary safeguard that protects the stability and functionality of otherwise easily misregulated gene expression programmes and signalling pathways of cancer cells.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Hypoxia
  • Cellular Senescence
  • DNA Damage
  • Drug Resistance, Neoplasm
  • Gene Expression Regulation
  • Humans
  • NF-kappa B / physiology
  • Neoplasms / etiology*
  • SUMO-1 Protein / physiology*
  • Signal Transduction / physiology
  • Sumoylation


  • NF-kappa B
  • SUMO-1 Protein