[ 18 F]FDG PET signal is driven by astroglial glutamate transport

Nat Neurosci. 2017 Mar;20(3):393-395. doi: 10.1038/nn.4492. Epub 2017 Jan 30.

Abstract

Contributions of glial cells to neuroenergetics have been the focus of extensive debate. Here we provide positron emission tomography evidence that activation of astrocytic glutamate transport via the excitatory amino acid transporter GLT-1 triggers widespread but graded glucose uptake in the rodent brain. Our results highlight the need for a reevaluation of the interpretation of [18F]FDG positron emission tomography data, whereby astrocytes would be recognized as contributing to the [18F]FDG signal.

MeSH terms

  • Animals
  • Astrocytes / metabolism*
  • Biological Transport
  • Brain / blood supply
  • Brain / drug effects
  • Brain / metabolism
  • Ceftriaxone / pharmacology
  • Cells, Cultured
  • Excitatory Amino Acid Transporter 1 / agonists
  • Excitatory Amino Acid Transporter 1 / physiology*
  • Fluorodeoxyglucose F18 / metabolism*
  • Functional Neuroimaging
  • Glutamic Acid / metabolism*
  • Locomotion / drug effects
  • Male
  • Positron-Emission Tomography
  • Rats
  • Vibrissae / physiology

Substances

  • Excitatory Amino Acid Transporter 1
  • Fluorodeoxyglucose F18
  • Glutamic Acid
  • Ceftriaxone