Ocular promoting activity of grape polyphenols-A review

Environ Toxicol Pharmacol. 2017 Mar:50:83-90. doi: 10.1016/j.etap.2016.12.004. Epub 2016 Dec 9.


The eye is a sensitive organ with complex optical system involves in the perception of light. Although it has several protective mechanisms by itself, various physiological and metabolic disorders are detrimental to the proper functioning of the visual system. Grape juice has long been used worldwide for its potent medicinal values including ocular promotion. Bioactivities of grape products are highly attributed to the presence of health promoting phytochemicals in them. Some phytochemicals present in the grape juice have been involved in the maintenance of intra-ocular pressure, regulation of glucose metabolisms and suppression of pro-inflammatory cytokines in the system. Particularly, the grape derived phytochemicals involve in minimizing various eye defects such as macular degradation, uvea, cataract formation, red eye, diabetic retinopathy and so on. However, only limited number of studies has been conducted so far focusing the ocular promoting activity of grape polyphenols. In this review, we discuss the role of grape polyphenols in ocular promotion relating their anti-oxidant, anti-microbial, anti-aging, anti-hypertensive and anti-inflammatory properties.

Keywords: Diabetes; Eye disease; Grape polyphenols; Hypertension; Ocular promotion.

Publication types

  • Review

MeSH terms

  • Anti-Infective Agents / pharmacology
  • Anti-Inflammatory Agents / pharmacology
  • Antihypertensive Agents / pharmacology
  • Antioxidants / pharmacology
  • Eye / drug effects*
  • Eye / microbiology
  • Eye / pathology
  • Humans
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology
  • Polyphenols / pharmacology*
  • Vitis / chemistry*


  • Anti-Infective Agents
  • Anti-Inflammatory Agents
  • Antihypertensive Agents
  • Antioxidants
  • Plant Extracts
  • Polyphenols