Regulation of Calcium Homeostasis by ER Redox: A Close-Up of the ER/Mitochondria Connection

J Mol Biol. 2017 Mar 10;429(5):620-632. doi: 10.1016/j.jmb.2017.01.017. Epub 2017 Jan 28.


Calcium signaling plays an important role in cell survival by influencing mitochondria-related processes such as energy production and apoptosis. The endoplasmic reticulum (ER) is the main storage compartment for cell calcium (Ca2+; ~60-500μM), and the Ca2+ released by the ER has a prompt effect on the homeostasis of the juxtaposed mitochondria. Recent findings have highlighted a close connection between ER redox and Ca2+ signaling that is mediated by Ca2+-handling proteins. This paper describes the redox-regulated mediators and mechanisms that orchestrate Ca2+ signals from the ER to mitochondria.

Keywords: IP3R; RyR; SERCA; mitochondria-associated membranes; redox-regulated calcium signaling.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Apoptosis
  • Calcium / metabolism*
  • Calcium Channels / metabolism
  • Calcium Signaling*
  • Endoplasmic Reticulum / metabolism*
  • Homeostasis*
  • Humans
  • Inositol 1,4,5-Trisphosphate Receptors / genetics
  • Inositol 1,4,5-Trisphosphate Receptors / metabolism
  • Mitochondria / metabolism*
  • Models, Molecular
  • Oxidation-Reduction
  • Protein Transport
  • Ryanodine Receptor Calcium Release Channel / metabolism
  • Voltage-Dependent Anion Channels / genetics
  • Voltage-Dependent Anion Channels / metabolism


  • Calcium Channels
  • Inositol 1,4,5-Trisphosphate Receptors
  • Ryanodine Receptor Calcium Release Channel
  • Voltage-Dependent Anion Channels
  • Calcium