Emergence of function from coordinated cells in a tissue

Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):1462-1467. doi: 10.1073/pnas.1621145114. Epub 2017 Jan 30.


This work presents a mathematical study of tissue dynamics. We combine within-cell genome dynamics and diffusion between cells, so that the synthesis of the two gives rise to the emergence of function, akin to establishing "tissue homeostasis." We introduce two concepts, monotonicity and a weak version of hardwiring. These together are sufficient for global convergence of the tissue dynamics.

Keywords: diffusion; emergence; genome dynamics; monotonicity; tissue dynamics.

MeSH terms

  • Algorithms
  • Cell Communication
  • Cell Physiological Phenomena*
  • Cells / metabolism
  • Diffusion
  • Genome
  • Homeostasis
  • Models, Biological*
  • Morphogenesis