Progressive Perforation of the Nasal Septum Due to Leishmania major: A Case of Mucosal Leishmaniasis in a Traveler

Am J Trop Med Hyg. 2017 Mar;96(3):653-655. doi: 10.4269/ajtmh.16-0809. Epub 2017 Apr 6.


This report describes a case of mucosal leishmaniasis caused by Leishmania major with destructive perforation of the nasal septum illustrating the diagnostic challenges of a rare clinical presentation of L. major infection in a traveler. The atypical presentation may have been associated with the use of cortisone as a potential trigger for the progressive destruction of the nasal septum.

Publication types

  • Case Reports

MeSH terms

  • Administration, Intravenous
  • Adult
  • Amphotericin B / therapeutic use
  • Humans
  • Leishmania major / isolation & purification*
  • Leishmaniasis, Mucocutaneous / diagnosis*
  • Leishmaniasis, Mucocutaneous / drug therapy
  • Male
  • Nasal Septum / parasitology*
  • Nasal Septum / pathology*


  • liposomal amphotericin B
  • Amphotericin B