[Oral antidiabetic drugs in treatment of type 1 diabetes mellitus]

Vnitr Lek. 2016 Winter;62(12):998-1003.
[Article in Czech]

Abstract

Review article summarizes current knowledge of the use of oral antidiabetics (approved for treatment of type 2 diabetes) in type 1 diabetic patients. Following drugs were tested: metformin, gliptines, analogues of GLP-1, glitazones, inhibitors of α-glukozidase and gliflozines. The latter seem to be the most perspective ones, however, more studies are warranted for definitive confirmation of their efficacy and safety. Current evidence-based results did not clearly show efficacy and safety of oral antidiabetics as adjuvant treatment in type 1 diabetic patients and thus, they still represent off-label treatment in this type of diabetes.Key words: oral antidiabetics - type 1 diabetes mellitus.

Publication types

  • Review

MeSH terms

  • Diabetes Mellitus, Type 1 / drug therapy*
  • Diabetes Mellitus, Type 1 / prevention & control
  • Dipeptidyl-Peptidase IV Inhibitors / therapeutic use
  • Glucagon-Like Peptide 1 / analogs & derivatives
  • Humans
  • Hypoglycemic Agents / therapeutic use*
  • Metformin / therapeutic use

Substances

  • Dipeptidyl-Peptidase IV Inhibitors
  • Hypoglycemic Agents
  • Glucagon-Like Peptide 1
  • Metformin