CPEB4 links the clock and the UPR to protect the liver

Nat Cell Biol. 2017 Jan 31;19(2):79-81. doi: 10.1038/ncb3460.


Under misfolded protein stress, the endoplasmic reticulum (ER) activates the unfolded protein response (UPR) to restore homeostasis, or commits the cell to apoptosis. A study now uncovers how the UPR is governed by the circadian clock to adjust ER protein-folding capacity to metabolic demand and protect against liver damage.

Publication types

  • News
  • Comment

MeSH terms

  • Animals
  • Endoplasmic Reticulum / metabolism*
  • Endoplasmic Reticulum Stress / physiology*
  • Homeostasis / physiology
  • Humans
  • Liver / metabolism*
  • RNA-Binding Proteins / metabolism*
  • Unfolded Protein Response / physiology*


  • CPEB4 protein, human
  • RNA-Binding Proteins