Timing of meals: when is as critical as what and how much

Am J Physiol Endocrinol Metab. 2017 May 1;312(5):E369-E380. doi: 10.1152/ajpendo.00295.2016. Epub 2017 Jan 31.

Abstract

Over the past decade, a large body of literature has demonstrated that disruptions of the endogenous circadian clock, whether environmental or genetic, lead to metabolic dysfunctions that are associated with obesity, diabetes, and other metabolic disorders. The phrase, "It is not only what you eat and how much you eat, but also when you eat" sends a simple message about circadian timing and body weight regulation. Communicating this message to clinicians and patients, while also elucidating the neuroendocrine, molecular, and genetic mechanisms underlying this phrase is essential to embrace the growing knowledge of the circadian impact on metabolism as a part of healthy life style as well as to incorporate it into clinical practice for improvement of overall human health. In this review, we discuss findings from animal models, as well as epidemiological and clinical studies in humans, which collectively promote the awareness of the role of circadian clock in metabolic functions and dysfunctions.

Keywords: circadian clock; metabolism; obesity.

Publication types

  • Review
  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Circadian Rhythm / physiology*
  • Eating / physiology*
  • Energy Metabolism / physiology*
  • Evidence-Based Medicine
  • Feeding Behavior / physiology*
  • Humans
  • Metabolic Diseases / diet therapy
  • Metabolic Diseases / physiopathology*
  • Models, Biological
  • Obesity / diet therapy
  • Obesity / physiopathology*
  • Time Factors