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, 68 (3), 253-260

Gastric Vascular and Motor Responses to Anaphylactic Hypotension in Anesthetized Rats, in Comparison to Those With Hemorrhagic or Vasodilator-Induced Hypotension

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Gastric Vascular and Motor Responses to Anaphylactic Hypotension in Anesthetized Rats, in Comparison to Those With Hemorrhagic or Vasodilator-Induced Hypotension

Yuhichi Kuda et al. J Physiol Sci.

Abstract

Anaphylactic shock is life-threatening, but pathophysiology of the stomach lesion remains unclear. We determined gastric hemodynamics and gastric functions during anaphylactic hypotension, as compared to hypotension induced by hemorrhage or sodium nitroprusside (SNP) in anesthetized and ovalbumin-sensitized Sprague-Dawley rats. Systemic arterial pressure, portal venous pressure, and gastric arterial blood flow were measured, and gastric vascular resistance (GVR) was determined. Separately, the intragastric pressure (IGP) and gastric effluent, as a measure of gastric flux, were continuously measured. During anaphylaxis, GVR decreased only transiently at 0.5 min, followed by an increase. IGP increased markedly, while gastric flux decreased. During hemorrhage, GVR and IGP increased, while gastric flux did not change. When SNP was injected, both GVR and IGP decreased and gastric flux increased only just after injection. In conclusion, gastric vasodilatation occurs only transiently after antigen injection, and gastric motility increases, but gastric emptying deceases during anaphylactic hypotension in anesthetized rats.

Keywords: Anaphylactic shock; Anesthetized rats; Gastric circulation; Gastric emptying; Gastric motility; Hemorrhage.

Conflict of interest statement

Conflict of interest

The authors declare that they have no conflicts of interest.

Funding

The present study was supported by a grant from Kanazawa Medical University (S2014-14).

Statement on the welfare of animals

All applicable international, national, and/or institutional guidelines for the care and use of animals were followed. All procedures performed in studies involving animals were in accordance with the ethical standards of the institution or practice at which the studies were conducted.

Figures

Fig. 1
Fig. 1
Representative recordings of the systemic arterial pressure, central venous pressure, portal venous pressure, gastric arterial blood flow, heart rate and gastric vascular resistance in the anaphylaxis (a), hemorrhage (b), and sodium nitroprusside (SNP) (c) groups
Fig. 2
Fig. 2
Time-course data of systemic arterial pressure (a), portal venous pressure (b), gastric arterial blood flow (c), and gastric vascular resistance (d), after the start of the interventions. Circle, the control group (n = 7); square, the anaphylaxis group (n = 7); inverted triangle, the hemorrhage group (n = 7); triangle, the SNP group (n = 7). Values are mean ± SEM; *p < 0.05 vs. baseline; # p < 0.05 vs. the control group
Fig. 3
Fig. 3
Representative recordings of the systemic arterial pressure, central venous pressure, intragastric pressure, gastric effluent weight, and heart rate in the anaphylaxis (a), hemorrhage (b), and SNP (c) groups
Fig. 4
Fig. 4
Time-course data of systemic arterial pressure (a), basal intragastric pressure (b), intragastric pressure amplitude (c), and gastric flux (d) in the anaphylaxis, hemorrhage, and SNP groups. Circle, the control group (n = 7); square, the anaphylaxis group (n = 7); inverted triangle, the hemorrhage group (n = 7); triangle, the SNP group (n = 7). Values are mean ± SEM; *p < 0.05 vs. baseline; # p < 0.05 vs. the control group

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