Diverse Profiles of Anxiety Related Disorders in Fragile X, Cornelia de Lange and Rubinstein-Taybi Syndromes

J Autism Dev Disord. 2017 Dec;47(12):3728-3740. doi: 10.1007/s10803-016-3015-y.

Abstract

Anxiety disorders are heightened in specific genetic syndromes in comparison to intellectual disability of heterogeneous aetiology. In this study, we described and contrasted anxiety symptomatology in fragile X (FXS), Cornelia de Lange (CdLS) and Rubinstein-Taybi syndromes (RTS), and compared the symptomatology to normative data for typically-developing children and children diagnosed with an anxiety disorder. Scores did not differ between children diagnosed with an anxiety disorder and (a) participants with FXS on social phobia, panic/agoraphobia, physical injury fears, and obsessive-compulsive subscales (b) participants with CdLS on separation anxiety, generalized anxiety, panic/agoraphobia, physical injury fears and obsessive-compulsive subscales, and (c) participants with RTS on panic/agoraphobia and obsessive-compulsive subscales. The results highlight divergent profiles of anxiety symptomatology between these groups.

Keywords: Anxiety; Cornelia de Lange syndrome; Fragile X syndrome; Genetic syndromes; Intellectual disability; Rubinstein–Taybi syndrome.

MeSH terms

  • Adolescent
  • Adult
  • Anxiety Disorders / diagnosis
  • Anxiety Disorders / genetics
  • Anxiety Disorders / psychology*
  • Child
  • De Lange Syndrome / diagnosis
  • De Lange Syndrome / genetics
  • De Lange Syndrome / psychology*
  • Female
  • Fragile X Syndrome / diagnosis
  • Fragile X Syndrome / genetics
  • Fragile X Syndrome / psychology*
  • Humans
  • Intellectual Disability / diagnosis
  • Intellectual Disability / genetics
  • Intellectual Disability / psychology
  • Male
  • Rubinstein-Taybi Syndrome / diagnosis
  • Rubinstein-Taybi Syndrome / genetics
  • Rubinstein-Taybi Syndrome / psychology*
  • Young Adult