Association between grip strength and diabetes prevalence in black, South-Asian, and white European ethnic groups: a cross-sectional analysis of 418 656 participants in the UK Biobank study

Diabet Med. 2017 Aug;34(8):1120-1128. doi: 10.1111/dme.13323. Epub 2017 Feb 23.

Abstract

Aims: To quantify the extent to which ethnic differences in muscular strength might account for the substantially higher prevalence of diabetes in black and South-Asian compared with white European adults.

Methods: This cross-sectional study used baseline data from the UK Biobank study on 418 656 white European, black and South-Asian participants, aged 40-69 years, who had complete data on diabetes status and hand-grip strength. Associations between hand-grip strength and diabetes were assessed using logistic regression and were adjusted for potential confounding factors.

Results: Lower grip strength was associated with higher prevalence of diabetes, independent of confounding factors, across all ethnicities in both men and women. Diabetes prevalence was approximately three- to fourfold higher in South-Asian and two- to threefold higher in black participants compared with white European participants across all levels of grip strength, but grip strength in South-Asian men and women was ~ 5-6 kg lower than in the other ethnic groups. Thus, the attributable risk for diabetes associated with low grip strength was substantially higher in South-Asian participants (3.9 and 4.2 cases per 100 men and women, respectively) than in white participants (2.0 and 0.6 cases per 100 men and women, respectively). Attributable risk associated with low grip strength was also high in black men (4.3 cases) but not in black women (0.4 cases).

Conclusions: Low strength is associated with a disproportionately large number of diabetes cases in South-Asian men and women and in black men. Trials are needed to determine whether interventions to improve strength in these groups could help reduce ethnic inequalities in diabetes prevalence.

Publication types

  • Multicenter Study
  • Observational Study

MeSH terms

  • Adult
  • African Continental Ancestry Group
  • Age Factors
  • Aged
  • Asian Continental Ancestry Group
  • Cohort Studies
  • Confounding Factors, Epidemiologic
  • Cross-Sectional Studies
  • Diabetes Complications / ethnology
  • Diabetes Complications / physiopathology*
  • Diabetes Mellitus / epidemiology*
  • Diabetes Mellitus / ethnology
  • European Continental Ancestry Group
  • Female
  • Hand Strength
  • Health Status Disparities
  • Humans
  • Male
  • Middle Aged
  • Muscle Weakness / complications
  • Muscle Weakness / ethnology
  • Muscle Weakness / physiopathology*
  • Prevalence
  • Risk Factors
  • Severity of Illness Index
  • Sex Factors
  • United Kingdom / epidemiology