Actions of Quercetin, a Polyphenol, on Blood Pressure

Molecules. 2017 Jan 29;22(2):209. doi: 10.3390/molecules22020209.


Disorder of blood pressure control causes serious diseases in the cardiovascular system. This review focuses on the anti-hypertensive action of quercetin, a flavonoid, which is one of the polyphenols characterized as the compounds containing large multiples of phenol structural units, by varying the values of various blood pressure regulatory factors, such as vascular compliance, peripheral vascular resistance, and total blood volume via anti-inflammatory and anti-oxidant actions. In addition to the anti-inflammatory and anti-oxidant actions of quercetin, we especially describe a novel mechanism of quercetin's action on the cytosolic Cl- concentration ([Cl-]c) and novel roles of the cytosolic Cl- i.e.: (1) quercetin elevates [Cl-]c by activating Na⁺-K⁺-2Cl- cotransporter 1 (NKCC1) in renal epithelial cells contributing to Na⁺ reabsorption via the epithelial Na⁺ channel (ENaC); (2) the quercetin-induced elevation of [Cl-]c in renal epithelial cells diminishes expression of ENaC leading to a decrease in renal Na⁺ reabsorption; and (3) this reduction of ENaC-mediated Na⁺ reabsorption in renal epithelial cells drops volume-dependent elevated blood pressure. In this review, we introduce novel, unique mechanisms of quercetin's anti-hypertensive action via activation of NKCC1 in detail.

Keywords: Na+-K+-2Cl− cotransporter 1; cytosolic Cl− concentration; epithelial Na+ channel; flavonoid; quercetin.

Publication types

  • Review

MeSH terms

  • Animals
  • Anti-Inflammatory Agents
  • Antihypertensive Agents / chemistry
  • Antihypertensive Agents / metabolism
  • Antihypertensive Agents / pharmacology*
  • Antihypertensive Agents / therapeutic use
  • Antioxidants
  • Blood Pressure / drug effects*
  • Chlorides / metabolism
  • Clinical Trials as Topic
  • Drug Evaluation, Preclinical
  • Epithelial Sodium Channels / genetics
  • Epithelial Sodium Channels / metabolism
  • Gene Expression Regulation / drug effects
  • Humans
  • Polyphenols / chemistry
  • Polyphenols / metabolism
  • Polyphenols / pharmacology*
  • Polyphenols / therapeutic use
  • Quercetin / chemistry
  • Quercetin / metabolism
  • Quercetin / pharmacology*
  • Quercetin / therapeutic use
  • Solute Carrier Family 12, Member 2 / metabolism


  • Anti-Inflammatory Agents
  • Antihypertensive Agents
  • Antioxidants
  • Chlorides
  • Epithelial Sodium Channels
  • Polyphenols
  • Solute Carrier Family 12, Member 2
  • Quercetin