Nanomaterials in Targeting Cancer Stem Cells for Cancer Therapy

Front Pharmacol. 2017 Jan 18;8:1. doi: 10.3389/fphar.2017.00001. eCollection 2017.

Abstract

Cancer stem cells (CSCs) have been identified in almost all cancers and give rise to metastases and can also act as a reservoir of cancer cells that may cause a relapse after surgery, radiation, or chemotherapy. Thus they are obvious targets in therapeutic approaches and also a great challenge in cancer treatment. The threat presented by CSCs lies in their unlimited proliferative ability and multidrug resistance. These findings have necessitated an effective novel strategy to target CSCs for cancer treatment. Nanomaterials are on the route to providing novel methods in cancer therapies. Although, there have been a large number of excellent work in the field of targeted cancer therapy, it remains an open question how nanomaterials can meet future demands for targeting and eradicating of CSCs. In this review, we summarized recent and highlighted future prospects for targeting CSCs for cancer therapies by using a variety of nanomaterials.

Keywords: cancer stem cells; multidrug resistance; nanomaterials; targeted therapies; unlimited proliferation.

Publication types

  • Review