Effects of curcumin on Helicobacter pylori infection

Ann Transl Med. 2016 Dec;4(24):479. doi: 10.21037/atm.2016.12.52.


Background: Curcumin is a well-established natural molecule with significant biological and pharmaceutical effects. Its effects on Helicobacter pylori (H. pylori) infection have been repeatedly confirmed both in animal and human models. This study directly compared five different samples to evaluate if the effects are general or if they differ among samples.

Methods: Using a mouse model, we studied the effects of curcumin on lipid peroxide (LPO) level, myeloperoxidase (MPO) and urease activity, number of colonized bacteria, levels of anti-H. pylori antibodies, biofilm formation, IFN-γ, IL-4, gastrin and somatostatin levels in serum, and minimum inhibitory concentration. In addition, we evaluated the effects on biofilm production and antibacterial antibody response.

Results: In all tests, one sample (Sabinsa) was consistently the most active.

Conclusions: All curcumin samples showed some anti-H. pylori effects, but only some of the tested samples had significant activity.

Keywords: Biofilm; Helicobacter pylori (H. pylori); curcumin.