Histone demethylases and their roles in cancer epigenetics

. 2016;1(2):34-40.

Histone demethylases and their roles in cancer epigenetics

Alexandra D'Oto¹, Qing-Wu Tian², Andrew M Davidoff¹, Jun Yang¹

Affiliations

¹ Department of Surgery, St Jude Children's Research Hospital, Memphis, USA.
² Department of Clinical Laboratory, The Affiliated Hospital of Qingdao University, China.

PMID: 28149961
PMCID: PMC5279889

Histone demethylases and their roles in cancer epigenetics

Alexandra D'Oto et al. J Med Oncol Ther. 2016.

. 2016;1(2):34-40.

Authors

Alexandra D'Oto¹, Qing-Wu Tian², Andrew M Davidoff¹, Jun Yang¹

Affiliations

¹ Department of Surgery, St Jude Children's Research Hospital, Memphis, USA.
² Department of Clinical Laboratory, The Affiliated Hospital of Qingdao University, China.

PMID: 28149961
PMCID: PMC5279889

Abstract

The genetic abnormalities that drive tumorigenesis are usually coupled with epigenetic alterations, such as DNA methylation and aberrant histone modifications, which may help oncogenic drivers accelerate cancer progression, metastasis, and therapy resistance. The discovery of histone demethylases has provided us new insight for understanding the epigenetic landscape of the chromatin environment of cancer cells. This review aims to summarize the current knowledge on the human histone lysine demethylases and their functions in cancers, and recent advances in development of small molecule inhibitors to target histone demethylases in cancer treatment.

Keywords: Cancer; Epigenetics; Histone demethylase.

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References

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[1] Shi Y, Whetstine JR. Dynamic regulation of histone lysine methylation by demethylases. Mol Cell. 2007;25:1–14. - PubMed

[2] Shi Y, Whetstine JR. Dynamic regulation of histone lysine methylation by demethylases. Mol Cell. 2007;25:1–14. - PubMed

[3] Rotili D, Mai A. Targeting histone demethylases: A new avenue for the fight against cancer. Genes Cancer. 2011;2:663–679. - PMC - PubMed

[4] Rotili D, Mai A. Targeting histone demethylases: A new avenue for the fight against cancer. Genes Cancer. 2011;2:663–679. - PMC - PubMed

[5] Nicholson TB, Chen T. LSD1 demethylates histone and nonhistone proteins. Epigenetics. 2009;4:129–132. - PubMed

[6] Nicholson TB, Chen T. LSD1 demethylates histone and nonhistone proteins. Epigenetics. 2009;4:129–132. - PubMed

[7] Ramadoss S, Guo G, Wang CY. Lysine demethylase KDM3A regulates breast cancer cell invasion and apoptosis by targeting histone and the non-histone protein p53. Oncogene. 2016 - PMC - PubMed

[8] Ramadoss S, Guo G, Wang CY. Lysine demethylase KDM3A regulates breast cancer cell invasion and apoptosis by targeting histone and the non-histone protein p53. Oncogene. 2016 - PMC - PubMed

[9] Hojfeldt JW, Agger K, Helin K. Histone lysine demethylases as targets for anticancer therapy. Nat Rev Drug Discov. 2013;12:917–930. - PubMed

[10] Hojfeldt JW, Agger K, Helin K. Histone lysine demethylases as targets for anticancer therapy. Nat Rev Drug Discov. 2013;12:917–930. - PubMed

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Histone demethylases and their roles in cancer epigenetics

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Histone demethylases and their roles in cancer epigenetics

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