Protein Bioinformatics Databases and Resources

Methods Mol Biol. 2017;1558:3-39. doi: 10.1007/978-1-4939-6783-4_1.


Many publicly available data repositories and resources have been developed to support protein-related information management, data-driven hypothesis generation, and biological knowledge discovery. To help researchers quickly find the appropriate protein-related informatics resources, we present a comprehensive review (with categorization and description) of major protein bioinformatics databases in this chapter. We also discuss the challenges and opportunities for developing next-generation protein bioinformatics databases and resources to support data integration and data analytics in the Big Data era.

Keywords: Big data; Bioinformatics; Data analytics; Data integration; Database; PTM; Pathway; Protein family; Protein function; Protein interaction; Protein mutation; Protein sequence; Protein structure; Proteomics.

Publication types

  • Review
  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Computational Biology / methods*
  • Databases, Genetic*
  • Genomics / methods
  • Humans
  • Proteins / genetics*
  • Proteins / metabolism*
  • Proteomics / methods*
  • Software*
  • Web Browser*


  • Proteins