Potential diagnostic and prognostic significance of plasma prolidase activity in gastric cancer

Biomark Med. 2017 Apr;11(4):319-327. doi: 10.2217/bmm-2016-0367. Epub 2017 Feb 2.

Abstract

Aim: Plasma prolidase activities (PPAs) in cases of gastric cancer.

Methodology/results: This study was based on a prospective design. 60 patients with gastric cancer (operable cases: 48; inoperable: 12) and 60 healthy controls were included in the study. Prolidase activity was analyzed. The mean PPA levels in the operable, inoperable and control groups were 45.60 ± 4.20, 54.35 ± 4. 9 and 10.92 ± 0.79 U/l, respectively (p < 0.001). PPA decreased significantly after tumor resection. PPA level was significant in differentiating operable cases from inoperable (sensitivity: 91.7%; specificity: 85.2%).

Discussion/conclusion: PPA was significantly higher in patients with inoperable gastric cancer than in operable cases and the control group. A strong correlation was found between tumor volume and PPA.

Keywords: enzymes; gastric cancer; prognostic factors; prolidase activity; tumor markers.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Area Under Curve
  • Biomarkers, Tumor / blood
  • Case-Control Studies
  • Dipeptidases / blood*
  • Female
  • Follow-Up Studies
  • Humans
  • Lymphatic Metastasis
  • Male
  • Middle Aged
  • Prognosis
  • Prospective Studies
  • ROC Curve
  • Stomach Neoplasms / diagnosis*
  • Stomach Neoplasms / mortality
  • Stomach Neoplasms / pathology
  • Survival Rate
  • Tumor Burden
  • Young Adult

Substances

  • Biomarkers, Tumor
  • Dipeptidases
  • proline dipeptidase