Cation Tuning of Supramolecular Gel Properties: A New Paradigm for Sustained Drug Delivery

Michael A Ramin; Kotagudda Ranganath Sindhu; Ananda Appavoo; Khalid Oumzil; Mark W Grinstaff; Olivier Chassande; Philippe Barthélémy

doi:10.1002/adma.201605227

Cation Tuning of Supramolecular Gel Properties: A New Paradigm for Sustained Drug Delivery

Adv Mater. 2017 Apr;29(13). doi: 10.1002/adma.201605227. Epub 2017 Feb 2.

Authors

Michael A Ramin¹, Kotagudda Ranganath Sindhu², Ananda Appavoo¹, Khalid Oumzil¹, Mark W Grinstaff³, Olivier Chassande², Philippe Barthélémy¹

Affiliations

¹ ARNA Laboratory, Inserm, U1212, CNRS 5320, Université de Bordeaux, F-33000, Bordeaux, France.
² Inserm, U1026, Université de Bordeaux, F-33000, Bordeaux, France.
³ Departments of Biomedical Engineering and Chemistry, Boston University, Boston, MA, 02215, USA.

PMID: 28151562
DOI: 10.1002/adma.201605227

Abstract

Hydrogels formed by the self-assembly of low-molecular-weight gelators (LMWGs) are promising scaffolds for drug-delivery applications. A new biocompatible hydrogel, resulting from the self-assembly of nucleotide-lipid salts can be safely injected in vivo. The resulting hydrogel provides sustained-release of protein for more than a week.

Keywords: amphiphiles; drug delivery; hydrogels; low-molecular-weight gels; supramolecular assemblies; sustained release.

MeSH terms

Animals
Biocompatible Materials / chemistry*
Cations / chemistry*
Cattle
Drug Delivery Systems*
Fluorescent Dyes / administration & dosage
Fluorescent Dyes / pharmacokinetics
Hydrogels / chemistry*
Hydrophobic and Hydrophilic Interactions
Lipids / chemistry
Materials Testing
Mice
Microscopy, Electron, Transmission
Rheology
Salts / chemistry
Serum Albumin, Bovine / administration & dosage
Serum Albumin, Bovine / pharmacokinetics
Static Electricity
Subcutaneous Absorption

Substances

Biocompatible Materials
Cations
Fluorescent Dyes
Hydrogels
Lipids
Salts
Serum Albumin, Bovine