Expression and prognostic significance of zinc fingers and homeoboxes family members in renal cell carcinoma

PLoS One. 2017 Feb 2;12(2):e0171036. doi: 10.1371/journal.pone.0171036. eCollection 2017.

Abstract

Zinc fingers and homeoboxes (ZHX) is a transcription repressor family that contains three members; ZHX1, ZHX2, and ZHX3. Although ZHX family members have been associated with the progression of cancer, their values as prognostic factors in cancer patients have been poorly examined. Renal cell carcinoma (RCC) is a highly heterogeneous, aggressive cancer that responds variably to treatment. Thus, prognostic molecular markers are required to evaluate disease progression and to improve the survival. In clear cell RCC (ccRCC), ZHX1 and ZHX3 expression were found to be down-regulated but ZHX2 was up-regulated, and the expressions of ZHX1 and ZHX3 were significantly associated with pathological stage. Furthermore, Kaplan-Meier and multivariate regression analysis showed that reduction in the mRNA expression of ZHX1 was associated with poorer survival. Taken together, the present study shows loss of ZHX1 is correlated with ccRCC progression and suggests it is an independent prognostic marker in ccRCC.

MeSH terms

  • Aged
  • Carcinoma, Renal Cell / genetics*
  • Carcinoma, Renal Cell / mortality
  • Carcinoma, Renal Cell / pathology
  • Female
  • Gene Expression Regulation, Neoplastic
  • Genes, Homeobox
  • Homeodomain Proteins / genetics*
  • Humans
  • Kaplan-Meier Estimate
  • Kidney Neoplasms / genetics*
  • Kidney Neoplasms / mortality
  • Kidney Neoplasms / pathology
  • Male
  • Middle Aged
  • Prognosis
  • Repressor Proteins / genetics*
  • Transcription Factors / genetics*
  • Zinc Fingers

Substances

  • Homeodomain Proteins
  • Repressor Proteins
  • Transcription Factors
  • ZHX1 protein, human
  • ZHX2 protein, human
  • ZHX3 protein, human

Grant support

This work was supported by by the National Research Foundation of Korea(NRF) grant funded by the Korea government(MSIP) (NRF-2016R1A2B4014593), the Medical Research Center (MRC) Program through the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIP) (NRF-2015R1A5A2009656) and a grant from the National R&D Program for Cancer Control, Ministry for Health, Welfare and Family Affairs, Republic of Korea (0920050). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.