SR Proteins: Binders, Regulators, and Connectors of RNA

Mol Cells. 2017 Jan;40(1):1-9. doi: 10.14348/molcells.2017.2319. Epub 2017 Jan 26.


Serine and arginine-rich (SR) proteins are RNA-binding proteins (RBPs) known as constitutive and alternative splicing regulators. As splicing is linked to transcriptional and post-transcriptional steps, SR proteins are implicated in the regulation of multiple aspects of the gene expression program. Recent global analyses of SR-RNA interaction maps have advanced our understanding of SR-regulated gene expression. Diverse SR proteins play partially overlapping but distinct roles in transcription-coupled splicing and mRNA processing in the nucleus. In addition, shuttling SR proteins act as adaptors for mRNA export and as regulators for translation in the cytoplasm. This mini-review will summarize the roles of SR proteins as RNA binders, regulators, and connectors from transcription in the nucleus to translation in the cytoplasm.

Keywords: RNA-binding proteins; SR proteins; export; splicing; transcription; translation.

Publication types

  • Review

MeSH terms

  • Arginine / genetics
  • Arginine / metabolism
  • Humans
  • Protein Binding
  • Protein Biosynthesis
  • RNA / genetics
  • RNA / metabolism*
  • RNA Splicing
  • Serine / genetics
  • Serine / metabolism
  • Serine-Arginine Splicing Factors / genetics
  • Serine-Arginine Splicing Factors / metabolism*


  • Serine-Arginine Splicing Factors
  • Serine
  • RNA
  • Arginine