Autoimmune Disease Manifestations in the Oral Cavity

Surg Pathol Clin. 2017 Mar;10(1):57-88. doi: 10.1016/j.path.2016.11.001. Epub 2016 Dec 28.


Immune-related disorders of the oral cavity may occur as primary disease process, secondary to systemic disease or neoplasm, or as a reaction to medications and other agents. The entities represented within this group may vary significantly by severity, clinical presentation, microscopic presentation, and special testing results. The selected immune-related conditions of the oral cavity in this article are categorized and presented by their prototypical tissue reaction patterns: vesiculobullous, including acantholytic and subepithelial separation; psoriasiform; spongiotic; and lichenoid reaction patterns.

Keywords: Geographic tongue; Lichen planus; Pemphigoid; Pemphigus; Pyostomatitis vegetans.

Publication types

  • Review

MeSH terms

  • Autoimmune Diseases / diagnosis
  • Autoimmune Diseases / pathology*
  • Diagnosis, Differential
  • Humans
  • Mouth Diseases / diagnosis
  • Mouth Diseases / immunology
  • Mouth Diseases / pathology*
  • Mouth Mucosa / pathology
  • Paraneoplastic Syndromes / diagnosis
  • Paraneoplastic Syndromes / immunology
  • Paraneoplastic Syndromes / pathology
  • Pemphigus / diagnosis
  • Pemphigus / immunology
  • Pemphigus / pathology
  • Prognosis