C21orf57 is a human homologue of bacterial YbeY proteins

Biochem Biophys Res Commun. 2017 Mar 11;484(3):612-617. doi: 10.1016/j.bbrc.2017.01.149. Epub 2017 Jan 30.


The product of the human C21orf57 (huYBEY) gene is predicted to be a homologue of the highly conserved YbeY proteins found in nearly all bacteria. We show that, like its bacterial and chloroplast counterparts, the HuYbeY protein is an RNase and that it retains sufficient function in common with bacterial YbeY proteins to partially suppress numerous aspects of the complex phenotype of an Escherichia coli ΔybeY mutant. Expression of HuYbeY in Saccharomyces cerevisiae, which lacks a YbeY homologue, results in a severe growth phenotype. This observation suggests that the function of HuYbeY in human cells is likely regulated through specific interactions with partner proteins similarly to the way YbeY is regulated in bacteria.

Keywords: C21orf57; RNase; YBEY; Yeast.

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • Chloroplasts / chemistry*
  • Chloroplasts / genetics*
  • Conserved Sequence / genetics
  • Escherichia coli Proteins / chemistry*
  • Escherichia coli Proteins / genetics*
  • Evolution, Molecular*
  • Metalloproteins / chemistry*
  • Metalloproteins / genetics*
  • Molecular Sequence Data
  • Ribonucleases / chemistry*
  • Ribonucleases / genetics*
  • Sequence Homology, Amino Acid*


  • Escherichia coli Proteins
  • Metalloproteins
  • YbeY protein, E coli
  • Ribonucleases
  • YBEY protein, human