When LIN41 Comes to a Fork in the Road, It Takes BOTH Paths: Translational Repression OR mRNA Decay, Depending on the Target Site Position

Mol Cell. 2017 Feb 2;65(3):375-377. doi: 10.1016/j.molcel.2017.01.018.


In this issue, Aeschimann et al. (2017) demonstrate that, depending on the target location site (5'UTR or 3'UTR), LIN41 triggers repression of translation or mRNA decay, suggesting that one factor may use two independent pathways of post-transcriptional gene regulation.

Keywords: RNA-binding protein; early development; gene regulation; mRNA decay; translation repression.

MeSH terms

  • 3' Untranslated Regions
  • 5' Untranslated Regions
  • Animals
  • Gene Expression Regulation
  • Humans
  • Protein Biosynthesis*
  • RNA Stability
  • RNA, Messenger / chemistry
  • RNA, Messenger / metabolism*
  • Transcription Factors / metabolism*


  • 3' Untranslated Regions
  • 5' Untranslated Regions
  • RNA, Messenger
  • Transcription Factors