Neurodevelopmental Outcomes of Preterm Infants Fed Human Milk: A Systematic Review

Clin Perinatol. 2017 Mar;44(1):69-83. doi: 10.1016/j.clp.2016.11.004. Epub 2016 Dec 23.

Abstract

The neurodevelopmental benefits of breast milk feedings for preterm infants have been controversial. However, the effect on preterm infant neurodevelopment is sustained into childhood. The effects of breast milk feeding during the neonatal period and the duration of breastfeeding display effects on cognition into adolescence. The volume of breast milk received is a key factor in these effects. Additionally, emerging studies support the effects of human milk on structural brain development, such as increased white matter development and increased cortical thickness. The components of breast milk thought to mediate improved cognitive outcomes include long-chain polyunsaturated fatty acids and human milk oligosaccharides.

Keywords: Brain; Donor milk; Human milk; Neurodevelopmental; Outcomes.

Publication types

  • Review
  • Systematic Review

MeSH terms

  • Arachidonic Acid*
  • Brain / growth & development*
  • Child Development*
  • Cognition*
  • Docosahexaenoic Acids*
  • Fatty Acids, Unsaturated
  • Humans
  • Infant, Newborn
  • Infant, Premature
  • Milk, Human / chemistry*
  • Neurodevelopmental Disorders / epidemiology*
  • Neurogenesis

Substances

  • Fatty Acids, Unsaturated
  • Docosahexaenoic Acids
  • Arachidonic Acid