Effects of aging on functional and structural brain connectivity

Neuroimage. 2017 Oct 15;160:32-40. doi: 10.1016/j.neuroimage.2017.01.077. Epub 2017 Feb 1.


Over the past decade there has been an enormous rise in the application of functional and structural connectivity approaches to explore the brain's intrinsic organization in healthy and clinical populations. The notion underlying the application of these approaches to study aging is that subtle age-related disruption of the brain's regional integrity and information flow across the brain, are expressed by age-related differences in functional and structural connectivity. In this review I will discus recent advances in our understanding of how age affects our brain's intrinsic organization, and I will share my perspective on potential challenges and future directions of the field.

Keywords: Aging; Brain networks; Connectivity; Diffusion MRI; Functional MRI.

Publication types

  • Review

MeSH terms

  • Aging / pathology*
  • Aging / physiology
  • Brain / physiopathology*
  • Brain Mapping / methods
  • Humans
  • Magnetic Resonance Imaging
  • Neural Pathways / physiopathology*