Association Between Serum Zinc Levels and the Risk of Parkinson's Disease: a Meta-Analysis

Biol Trace Elem Res. 2017 Sep;179(1):45-51. doi: 10.1007/s12011-017-0941-2. Epub 2017 Feb 3.


Recent studies have found that the serum zinc levels were associated with the risk of Parkinson's disease (PD), but the results were inconsistent. Thus, we conducted a meta-analysis to summarize the evidence from observational studies between them. Pertinent studies were identified by a search in PubMed, Embase, and Web of science up to July, 10, 2016. Standardized mean difference (SMD) and 95% confidence intervals (CI) with random-effect model was used to combine the results. Subgroup analysis and meta-regression were also conducted. Publication bias was estimated using Begg's regression asymmetry test. A total of 11 articles involving 822 PD patients and 777 healthy controls were included in the meta-analysis. Our meta-analysis results revealed that the serum zinc levels in PD patients were significantly lower than those in health controls (SMD = -0.779, 95%CI = [-1.323, -0.234], P < 0.001). The association was also significant oriental studies (SMD = -1.601, 95%CI = [-2.398, -0.805], P < 0.001). No publication bias was found. The current study indicated that serum zinc levels in PD patients were significantly lower than those in healthy controls.

Keywords: Meta-analysis; Parkinson’s disease; Serum zinc levels.

Publication types

  • Meta-Analysis
  • Review

MeSH terms

  • Humans
  • Parkinson Disease / blood*
  • Risk Factors
  • Zinc / blood*


  • Zinc