Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2017 Apr;45:31-36.
doi: 10.1016/j.coi.2016.12.002. Epub 2017 Feb 1.

Murine Models of Germinal Center Derived-Lymphomas

Affiliations
Free PMC article
Review

Murine Models of Germinal Center Derived-Lymphomas

Parham Ramezani-Rad et al. Curr Opin Immunol. .
Free PMC article

Abstract

The germinal center (GC) reaction is an adaptive immune response to select B cells bearing high-affinity B cell receptors (BCRs) to undergo further differentiation into antibody-producing cells or memory B cells. To drive affinity maturation, (GC) B cells undergo rounds of hypermutation and rapid proliferation, which can enhance susceptibility to malignant transformation. Lymphomas frequently originate from GC B cells, but the etiology for most lymphoma subtypes is unknown. Work in the past decade has more fully documented the mutational landscape in lymphomas, but the impact of these genomic lesions is often difficult to ascertain. In addition, while mutations affecting BCR signaling are well studied, the impact of extrinsic microenvironmental factors has not been widely addressed. Murine models are useful tools to study lymphomagenesis and disease progression, as well as potential treatment in a pre-clinical setting. Herein we discuss advances in murine models of lymphoma and how they inform on key characteristics of human lymphomas.

Figures

Figure 1
Figure 1
The germinal center reaction and cell of origin in germinal center-derived B lymphomas. In the germinal center (GC), GC B cells undergo clonal expansion in the dark zone (DZ) and are positively selected in the light zone (LZ). In the LZ, follicular dendritic cells (FDC) retain antigen and cooperate with follicular helper T (Tfh) cells to support competitive GC B cells for survival and either differentiation or iterative rounds of cell division in the DZ. Several pathways are differentially regulated in DZ and LZ GC B cells. Mutations in these pathways manifest to different degrees in human B cell non-Hodgkin lymphoma (B-NHL) derived from GC B cells. The oncogenic potential of the highlighted pathways has been mechanistically assessed in murine models of B-NHL.

Similar articles

See all similar articles

Cited by 2 articles

Substances

Feedback