Blistering eruptions in childhood Henoch-Schönlein syndrome: systematic review of the literature

Eur J Pediatr. 2017 Apr;176(4):487-492. doi: 10.1007/s00431-017-2858-3. Epub 2017 Feb 4.


The occurrence of blistering eruptions in childhood Henoch-Schönlein syndrome has been so far addressed exclusively in individual case reports. To describe epidemiology, clinical presentation, and therapeutic options in Henoch-Schönlein patients ≤18 years of age with blistering eruptions, we completed a systematic literature search. For the final analysis, we retained 39 reports. Ten children with blisters were found in 7 (1.5%) case series containing a total of 666 unselected pediatric Henoch-Schönlein cases. We also found 41 individually documented cases of Henoch-Schönlein syndrome with blistering eruptions. Blistering eruptions and purpura were distributed very similarly, blisters developed concomitantly with palpable purpura or with a latency of ≤14 days, and 80% of the cases remitted within 4 weeks with a similar course in children managed expectantly and in those managed with steroids.

Conclusion: Blistering eruptions are rare in Henoch-Schönlein syndrome. They can be a source of diagnostic dilemma but do not have any prognostic value since they almost always spontaneously subside within 4 weeks. What is known: • Textbooks and reviews marginally refer to the occurrence of blistering eruptions in children with Henoch-Schönlein syndrome. What is new • Blistering eruptions occur in <2% of cases. • Blisters and purpura are distributed similarly, blisters develop concomitantly with purpura or with a latency of ≤14 days. • Almost all cases remit within 4 weeks with a similar course in children managed expectantly and in those managed with systemic steroids.

Keywords: Blister; Colchicine; Glucocorticoids; Purpura; Schönlein-Henoch; Vasculitis.

Publication types

  • Review
  • Systematic Review

MeSH terms

  • Blister / diagnosis
  • Blister / epidemiology
  • Blister / etiology*
  • Child
  • Female
  • Humans
  • IgA Vasculitis / complications*
  • IgA Vasculitis / drug therapy
  • Male
  • Skin Diseases, Vascular / diagnosis
  • Skin Diseases, Vascular / drug therapy
  • Steroids / therapeutic use


  • Steroids