Probabilistic conversion of neurosurgical DBS electrode coordinates into MNI space

Neuroimage. 2017 Apr 15;150:395-404. doi: 10.1016/j.neuroimage.2017.02.004. Epub 2017 Feb 3.

Abstract

In neurosurgical literature, findings such as deep brain stimulation (DBS) electrode positions are conventionally reported in relation to the anterior and posterior commissures of the individual patient (AC/PC coordinates). However, the neuroimaging literature including neuroanatomical atlases, activation patterns, and brain connectivity maps has converged on a different population-based standard (MNI coordinates). Ideally, one could relate these two literatures by directly transforming MRIs from neurosurgical patients into MNI space. However obtaining these patient MRIs can prove difficult or impossible, especially for older studies or those with hundreds of patients. Here, we introduce a methodology for mapping an AC/PC coordinate (such as a DBS electrode position) to MNI space without the need for MRI scans from the patients themselves. We validate our approach using a cohort of DBS patients in which MRIs are available, and test whether several variations on our approach provide added benefit. We then use our approach to convert previously reported DBS electrode coordinates from eight different neurological and psychiatric diseases into MNI space. Finally, we demonstrate the value of such a conversion using the DBS target for essential tremor as an example, relating the site of the active DBS contact to different MNI atlases as well as anatomical and functional connectomes in MNI space.

Publication types

  • Validation Study

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Atlases as Topic*
  • Brain / anatomy & histology*
  • Brain Mapping / methods*
  • Brain Mapping / standards
  • Deep Brain Stimulation / methods
  • Female
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged