[Antidiarrheal and anti-inflammatory effects of berberine]

Zhongguo Yao Li Xue Bao. 1989 Mar;10(2):174-6.
[Article in Chinese]


Berberine sulfate (Ber) 40 and 80 mg/kg ig reduced the purging effects of castor oil or Cassia angustifolia leaf in mice, but did not affect the gastrointestinal transport function of Chinese ink in normal mice. Ber 60 mg/kg ig significantly inhibited the increased vascular permeability induced by ip 0.7% acetic acid in mice. Ber 20 and 50 mg/kg sc markedly inhibited the increased vascular permeability induced by histamine 100 micrograms/0.1 ml ic in rats. Ber 4 and 8 mg/kg sc produced obvious inhibition in the xylene-induced swelling of mouse ear. The anti-inflammatory effects were enhanced in a dose-dependent manner. It is suggested that the antidiarrheal effect of Ber is relative to its restriction against exudative inflammation to a certain extent.

Publication types

  • English Abstract

MeSH terms

  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal*
  • Berberine / pharmacology*
  • Berberine / therapeutic use
  • Berberine Alkaloids / pharmacology*
  • Capillary Permeability / drug effects
  • Diarrhea / drug therapy*
  • Female
  • Gastrointestinal Motility / drug effects
  • Male
  • Mice
  • Rats
  • Rats, Inbred Strains


  • Anti-Inflammatory Agents, Non-Steroidal
  • Berberine Alkaloids
  • Berberine