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Review
. 2017;14(11):1149-1154.
doi: 10.2174/1567205014666170203125942.

Biomarkers for Alzheimer's Disease Diagnosis

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Free PMC article
Review

Biomarkers for Alzheimer's Disease Diagnosis

Vasileios Mantzavinos et al. Curr Alzheimer Res. .
Free PMC article

Abstract

Objective: The dramatic increase in the population with dementia expected in the next decades is accompanied by the establishment of novel and innovated methods that will offer accurate and efficient detection of the disease in its early stages. While Alzheimer's disease is the most common cause of dementia, by the time it is typically diagnosed, substantial neuronal loss and neuropathological lesions can damage many brain regions. The aim of this study is to investigate the main risk factors that affect and increase Alzheimer's disease progression over time even in cases with no significant memory impairment present. Several potential markers are discussed such as oxidative stress, metal ions, vascular disorders, protein dysfunctions and alterations in the mitochondrial populations.

Conclusion: A multiparametric model of Alzheimer's biomarkers is presented according to the latest classification of the disease.

Keywords: Alzheimer's disease biomarkers; metal ions; mild cognitive impairment; mitochondrial dynamics; oxidative stress; protein dysfunctions; vascular disorders.

Figures

Fig. (1)
Fig. (1)
Alzheimer's disease classification based on potential biomarkers.

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References

    1. Kukull W.A., Bowen J.D. Dementia epidemiology. Med. Clin. North Am. 2002;86:573–590. - PubMed
    1. DeKosky S.T., Marek K. Looking backward to move forward: early detection of neurodegenerative disorders. Science. 2003;302:830–834. - PubMed
    1. Dickerson B.C., Salat D.H., Greve D.N., Chua E.F., Rand-Giovannetti E., Rentz D.M., et al. Sperling RA increased hippocampal activation in mild cognitive impairment compared to normal aging and AD. Neurology. 2005;65(3):404–411. - PMC - PubMed
    1. Dubois B., Feldman H.H., Jacova C., Dekosky S.T., Barberger-Gateau P., et al. Scheltens P research criteria for the diagnosis of Alzheimer’s disease: revising the NINCDS-ADRDA criteria. Lancet Neurol. 2007;6(8):734–746. - PubMed
    1. Dickerson B.C., Sperling R.A. Functional abnormalities of the medial temporal lobe memory system in mild cognitive impairment and Alzheimer’s disease: insights from functional MRI studies. Neuropsychologia. 2008;46(6):1624–1635. - PMC - PubMed

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