Fecal Microbiota Transplantation

Gastroenterol Clin North Am. 2017 Mar;46(1):171-185. doi: 10.1016/j.gtc.2016.09.012.


Fecal microbiota transplantation (FMT) is the transfer of stool from a healthy donor into the colon of a patient whose disease is a result of an altered microbiome, with the goal of restoring the normal microbiota and thus curing the disease. The most effective and well-studied indication for FMT is recurrent Clostridium difficile infection. At this time, there is insufficient evidence to recommend FMT for other gastrointestinal diseases, but studies are under way. There is also insufficient evidence to recommend FMT for nongastrointestinal diseases at this time. The field is rapidly emerging.

Keywords: Clostridium difficile; FMT; Fecal microbiota transplant; Microbiome; Stool transplant.

Publication types

  • Review

MeSH terms

  • Clostridioides difficile*
  • Clostridium Infections / therapy*
  • Donor Selection
  • Dysbiosis / therapy*
  • Fecal Microbiota Transplantation* / adverse effects
  • Fecal Microbiota Transplantation* / methods
  • Humans
  • Inflammatory Bowel Diseases / therapy
  • Informed Consent
  • Patient Selection*