Troponin T levels associated with genetic variants in NOTCH2 and MTNR1B in women with psychosis

Psychiatry Res. 2017 Apr;250:217-220. doi: 10.1016/j.psychres.2017.01.030. Epub 2017 Jan 20.

Abstract

Psychosis patients have increased prevalence of metabolic disorders, which increase the risk for cardiovascular disease. Elevated troponin T level is an early biomarker of cardiovascular damage. We tested for association between troponin T levels and genetic risk variants of elevated blood glucose level in psychosis. Glucose and troponin T levels correlated positively. MTNR1B rs10830963 and NOTCH2 rs10923931 associated with troponin T levels in women, adjusted for glucose levels. These findings may indicate metabolic genetic influences on troponin T levels among women with psychosis.

Keywords: Cardiovascular biomarker; Schizophrenia; Type 2 diabetes.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Blood Glucose / metabolism
  • Cross-Sectional Studies
  • Female
  • Genetic Variation / genetics*
  • Glucose / metabolism
  • Glucose Tolerance Test
  • Humans
  • Male
  • Middle Aged
  • Polymorphism, Single Nucleotide / genetics
  • Psychotic Disorders / blood*
  • Psychotic Disorders / genetics*
  • Receptor, Melatonin, MT2 / genetics*
  • Receptor, Notch2 / genetics*
  • Risk Factors
  • Troponin T / blood*

Substances

  • Blood Glucose
  • MTNR1B protein, human
  • NOTCH2 protein, human
  • Receptor, Melatonin, MT2
  • Receptor, Notch2
  • Troponin T
  • Glucose