Oropouche Virus: Clinical, Epidemiological, and Molecular Aspects of a Neglected Orthobunyavirus

Am J Trop Med Hyg. 2017 May;96(5):1019-1030. doi: 10.4269/ajtmh.16-0672. Epub 2017 Feb 6.


AbstractOropouche virus (OROV) is an important cause of arboviral illness in Latin American countries, more specifically in the Amazon region of Brazil, Venezuela and Peru, as well as in other countries such as Panama. In the past decades, the clinical, epidemiological, pathological, and molecular aspects of OROV have been published and provide the basis for a better understanding of this important human pathogen. Here, we describe the milestones in a comprehensive review of OROV epidemiology, pathogenesis, and molecular biology, including a description of the first isolation of the virus, the outbreaks during the past six decades, clinical aspects of OROV infection, diagnostic methods, genome and genetic traits, evolution, and viral dispersal.

Publication types

  • Review

MeSH terms

  • Animals
  • Birds / virology
  • Brazil / epidemiology
  • Bunyaviridae Infections / diagnosis
  • Bunyaviridae Infections / epidemiology*
  • Bunyaviridae Infections / physiopathology
  • Bunyaviridae Infections / transmission
  • Ceratopogonidae / virology
  • Chromosome Mapping
  • Culex / virology
  • Disease Outbreaks*
  • Disease Vectors
  • Genome, Viral*
  • Genotype*
  • Humans
  • Orthobunyavirus / classification
  • Orthobunyavirus / genetics*
  • Orthobunyavirus / isolation & purification
  • Panama / epidemiology
  • Peru / epidemiology
  • Sloths / virology
  • Venezuela / epidemiology