Fat-soluble-vitamin status during the first year of life in infants with cystic fibrosis identified by screening of newborns

Am J Clin Nutr. 1989 Nov;50(5):1064-71. doi: 10.1093/ajcn/50.5.1064.


We investigated the fat-soluble-vitamin status during the first year of life in 36 infants with cystic fibrosis (CF) consecutively identified by screening of newborns. At initial evaluation (at age 51.0 +/- 26.7 d) 36% of patients were hypoalbuminemic, 21% had low serum retinol, 35% had low serum 25-hydroxyvitamin D. 38% had low serum alpha-tocopherol and low ratios of serum vitamin E to total lipids, and none had elevated protein in vitamin K absence (PIVKA). Hypoalbuminemia was more common in breast-fed than in formula-fed infants. Seventy-two-hour fecal fat excretion correlated inversely with serum alpha-tocopherol. Treatment with oral pancreatic enzyme supplements, a multiple vitamin, and additional vitamin E was associated with normalization of serum albumin, retinol, and 25-hydroxyvitamin D and negative PIVKA at age 6 and 12 mo. Approximately 10% of patients remained vitamin E deficient. Biochemical evidence of fat-soluble-vitamin deficiencies is common before age 3 mo in patients with CF and, except for vitamin E, these deficiencies corrected with standard therapy.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Child, Preschool
  • Cystic Fibrosis / blood*
  • Cystic Fibrosis / diagnosis
  • Female
  • Humans
  • Hydroxycholecalciferols / blood
  • Infant
  • Infant Nutrition Disorders / blood
  • Infant Nutrition Disorders / diagnosis
  • Infant, Newborn
  • Lipids / blood
  • Male
  • Neonatal Screening*
  • Nutritional Status*
  • Solubility
  • Vitamin A / blood
  • Vitamin E / blood
  • Vitamin K / blood
  • Vitamins / blood*


  • Hydroxycholecalciferols
  • Lipids
  • Vitamins
  • Vitamin A
  • Vitamin K
  • Vitamin E