Lipid Metabolism Fuels Cancer's Spread

Zhuo Li; Yibin Kang

doi:10.1016/j.cmet.2017.01.016

Lipid Metabolism Fuels Cancer's Spread

Cell Metab. 2017 Feb 7;25(2):228-230. doi: 10.1016/j.cmet.2017.01.016.

Authors

Zhuo Li¹, Yibin Kang²

Affiliations

¹ Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.
² Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA. Electronic address: ykang@princeton.edu.

PMID: 28178563
DOI: 10.1016/j.cmet.2017.01.016

Abstract

The ability to prospectively identify metastasis-initiating cells is essential for developing new anti-metastasis therapeutics. In a recent issue of Nature, Pascual et al. (2017) demonstrate that the fatty acid receptor CD36 marks a subpopulation of cancer cells with unique metastasis-initiating potential, highlighting a key role of lipid metabolism in metastatic colonization.

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MeSH terms

Carrier Proteins
Fatty Acids
Humans
Lipid Metabolism*
Neoplasms*

Substances

Carrier Proteins
Fatty Acids