WNK Kinase Signaling in Ion Homeostasis and Human Disease

Cell Metab. 2017 Feb 7;25(2):285-299. doi: 10.1016/j.cmet.2017.01.007.


WNK kinases, along with their upstream regulators (CUL3/KLHL3) and downstream targets (the SPAK/OSR1 kinases and the cation-Cl- cotransporters [CCCs]), comprise a signaling cascade essential for ion homeostasis in the kidney and nervous system. Recent work has furthered our understanding of the WNKs in epithelial transport, cell volume homeostasis, and GABA signaling, and uncovered novel roles for this pathway in immune cell function and cell proliferation.

Keywords: GABA; KCC2; KCC3; NCC; NKCC1; WNK1; WNK3; WNK4; chloride; homeostasis; kidney.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't
  • Research Support, N.I.H., Extramural

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Biological Transport
  • Cell Size
  • Disease*
  • Homeostasis*
  • Humans
  • Ions
  • Protein-Serine-Threonine Kinases / metabolism*
  • Signal Transduction*


  • Ions
  • Protein-Serine-Threonine Kinases