Inflammation, metaflammation and immunometabolic disorders

Nature. 2017 Feb 8;542(7640):177-185. doi: 10.1038/nature21363.

Abstract

Proper regulation and management of energy, substrate diversity and quantity, as well as macromolecular synthesis and breakdown processes, are fundamental to cellular and organismal survival and are paramount to health. Cellular and multicellular organization are defended by the immune response, a robust and critical system through which self is distinguished from non-self, pathogenic signals are recognized and eliminated, and tissue homeostasis is safeguarded. Many layers of evolutionarily conserved interactions occur between immune response and metabolism. Proper maintenance of this delicate balance is crucial for health and has important implications for many pathological states such as obesity, diabetes, and other chronic non-communicable diseases.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adaptive Immunity / genetics
  • Animals
  • Clinical Trials as Topic
  • Cytokines / metabolism
  • Evolution, Molecular
  • Genome-Wide Association Study
  • Hormones / metabolism
  • Humans
  • Inflammation / complications
  • Inflammation / genetics
  • Inflammation / immunology*
  • Inflammation / metabolism*
  • Invertebrates / immunology
  • Invertebrates / metabolism
  • Metabolic Diseases / complications
  • Metabolic Diseases / genetics
  • Metabolic Diseases / immunology*
  • Metabolic Diseases / metabolism*
  • Obesity / complications
  • Obesity / genetics
  • Obesity / immunology
  • Obesity / metabolism
  • Organelles / metabolism
  • Signal Transduction

Substances

  • Cytokines
  • Hormones