Strange New World: Bacteria Catalyze Ubiquitylation via ADP Ribosylation

Cell Host Microbe. 2017 Feb 8;21(2):127-129. doi: 10.1016/j.chom.2017.01.014.


Three recent papers, including one by Kotewicz et al. (2016) in this issue of Cell Host & Microbe, show that Legionella deploys a novel form of ubiquitylation to generate its replicative vacuole. Without E1 and E2 enzymes, SidE effectors ubiquitylate serine residues in substrates via an ADP-ribosylated ubiquitin intermediate.

Publication types

  • Comment

MeSH terms

  • Adenosine Diphosphate Ribose*
  • Bacteria
  • Humans
  • Serine
  • Ubiquitin
  • Ubiquitination*


  • Ubiquitin
  • Adenosine Diphosphate Ribose
  • Serine