Acute effects of nicotine-free and flavour-free electronic cigarette use on lung functions in healthy and asthmatic individuals

Respir Res. 2017 Feb 10;18(1):33. doi: 10.1186/s12931-017-0518-9.


We designed a crossover and placebo-controlled trial to investigate the impact of a 1-h acute vaping session of nicotine-free and flavour-free e-liquid on the pulmonary functions and respiratory mechanics of healthy and asthmatic individuals. This study shows that a 1-h vaping session of a high-grade and contaminant-free mixture of propylene glycol and glycerol using a commercially available electronic cigarette performed in a controlled environment does not significantly impact pulmonary functions, respiratory mechanics or symptoms in healthy or asthmatic subjects.

Publication types

  • Letter
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Inhalation
  • Adult
  • Asthma / physiopathology*
  • Cross-Over Studies
  • Female
  • Glycerol / administration & dosage
  • Glycerol / adverse effects*
  • Humans
  • Lung / physiopathology*
  • Male
  • Nicotine
  • Placebo Effect
  • Propylene Glycol / administration & dosage
  • Propylene Glycol / adverse effects*
  • Respiratory Function Tests*
  • Vaping / adverse effects*


  • Propylene Glycol
  • Nicotine
  • Glycerol