Transethnic genome-wide scan identifies novel Alzheimer's disease loci

Alzheimers Dement. 2017 Jul;13(7):727-738. doi: 10.1016/j.jalz.2016.12.012. Epub 2017 Feb 7.


Introduction: Genetic loci for Alzheimer's disease (AD) have been identified in whites of European ancestry, but the genetic architecture of AD among other populations is less understood.

Methods: We conducted a transethnic genome-wide association study (GWAS) for late-onset AD in Stage 1 sample including whites of European Ancestry, African-Americans, Japanese, and Israeli-Arabs assembled by the Alzheimer's Disease Genetics Consortium. Suggestive results from Stage 1 from novel loci were followed up using summarized results in the International Genomics Alzheimer's Project GWAS dataset.

Results: Genome-wide significant (GWS) associations in single-nucleotide polymorphism (SNP)-based tests (P < 5 × 10-8) were identified for SNPs in PFDN1/HBEGF, USP6NL/ECHDC3, and BZRAP1-AS1 and for the interaction of the (apolipoprotein E) APOE ε4 allele with NFIC SNP. We also obtained GWS evidence (P < 2.7 × 10-6) for gene-based association in the total sample with a novel locus, TPBG (P = 1.8 × 10-6).

Discussion: Our findings highlight the value of transethnic studies for identifying novel AD susceptibility loci.

Keywords: APOE interaction; Alzheimer's disease; Genome-wide association; Transethnic.

MeSH terms

  • Adaptor Proteins, Signal Transducing / genetics
  • Alzheimer Disease / genetics*
  • Apolipoprotein E4 / genetics
  • GTPase-Activating Proteins / genetics
  • Genetic Predisposition to Disease
  • Genome-Wide Association Study*
  • Heparin-binding EGF-like Growth Factor / genetics
  • Humans
  • Membrane Glycoproteins / genetics
  • Molecular Chaperones / genetics
  • NFI Transcription Factors / genetics
  • Peroxisomal Bifunctional Enzyme / genetics
  • Polymorphism, Single Nucleotide*
  • Receptors, GABA / genetics


  • Adaptor Proteins, Signal Transducing
  • Apolipoprotein E4
  • GTPase-Activating Proteins
  • HBEGF protein, human
  • Heparin-binding EGF-like Growth Factor
  • Membrane Glycoproteins
  • Molecular Chaperones
  • NFI Transcription Factors
  • NFIC protein, human
  • Receptors, GABA
  • TSPO protein, human
  • USP6NL protein, human
  • prefoldin
  • trophoblastic glycoprotein 5T4, human
  • EHHADH protein, human
  • Peroxisomal Bifunctional Enzyme

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