Nanoscale size effect in in situ titanium based composites with cell viability and cytocompatibility studies

Mater Sci Eng C Mater Biol Appl. 2017 Apr 1;73:525-536. doi: 10.1016/j.msec.2016.12.100. Epub 2016 Dec 23.


Novel in situ Metal Matrix Nanocomposite (MMNC) materials based on titanium and boron, revealed their new properties in the nanoscale range. In situ nanocomposites, obtained through mechanical alloying and traditional powder metallurgy compaction and sintering, show obvious differences to their microstructural analogue. A unique microstructure connected with good mechanical properties reliant on the processing conditions favour the nanoscale range of results of the Ti-TiB in situ MMNC example. The data summarised in this work, support and extend the knowledge boundaries of the nanoscale size effect that influence not only the mechanical properties but also the studies on the cell viability and cytocompatibility. Prepared in the same bulk, in situ MMNC, based on titanium and boron, could be considered as a possible candidate for dental implants and other medical applications. The observed relations and research conclusions are transferable to the in situ MMNC material group. Aside from all the discussed relations, the increasing share of these composites in the ever-growing material markets, heavily depends on the attractiveness and a possible wider application of these composites as well as their operational simplicity presented in this work.

Keywords: Cell viability and cytocompatibility; In situ TiB; Mechanical alloying; Nanoscale; Titanium metal matrix composite.

MeSH terms

  • Biocompatible Materials / pharmacology*
  • Cell Cycle / drug effects
  • Cell Line
  • Cell Survival / drug effects
  • Elastic Modulus
  • Fibroblasts / cytology*
  • Fibroblasts / drug effects
  • Humans
  • Materials Testing*
  • Nanoparticles / chemistry*
  • Osteoblasts / cytology*
  • Osteoblasts / drug effects
  • Particle Size*
  • Porosity
  • Powders
  • Titanium / pharmacology*
  • X-Ray Diffraction


  • Biocompatible Materials
  • Powders
  • Titanium