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Comment
. 2017 Feb 21;114(8):1753-1755.
doi: 10.1073/pnas.1700190114. Epub 2017 Feb 9.

Losing pieces without disintegrating: Contractile protein loss during muscle atrophy

Stefano Schiaffino  1
Affiliations
Free PMC article
Comment

Losing pieces without disintegrating: Contractile protein loss during muscle atrophy

Stefano Schiaffino. Proc Natl Acad Sci U S A. .
Free PMC article
No abstract available

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Conflict of interest statement

The author declares no conflict of interest.

Figures

Fig. 1.
Fig. 1.
The upper panel shows a longitudinal section of a rat skeletal muscle fiber visualized by electron microscopy. The cytoplasm is filled with myofibrils, which consist of sarcomeres arranged in series and bordered by Z disks (Z). The lower panel shows a scheme of two adjacent sarcomeres with thick (myosin) and thin (actin) filaments. Z disks are connected by transversally oriented desmin filaments (D). Two crucial steps in the dismantling of the sarcomeres during muscle atrophy are illustrated: first, the TRIM32-induced ubiquitination (u) of desmin filaments, thin filaments, and Z-disk proteins, followed by the PAX4-dependent up-regulation of p97, which is responsible for the extraction of ubiquitinated proteins (uP) from the sarcomeres before their degradation in the proteasome.
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