Implementing Genome-Driven Oncology

Cell. 2017 Feb 9;168(4):584-599. doi: 10.1016/j.cell.2016.12.015.


Early successes in identifying and targeting individual oncogenic drivers, together with the increasing feasibility of sequencing tumor genomes, have brought forth the promise of genome-driven oncology care. As we expand the breadth and depth of genomic analyses, the biological and clinical complexity of its implementation will be unparalleled. Challenges include target credentialing and validation, implementing drug combinations, clinical trial designs, targeting tumor heterogeneity, and deploying technologies beyond DNA sequencing, among others. We review how contemporary approaches are tackling these challenges and will ultimately serve as an engine for biological discovery and increase our insight into cancer and its treatment.

Keywords: Precision medicine; basket studies; genome-driven oncology; next-generation sequencing; targeted therapy.

Publication types

  • Review
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Drug Resistance, Neoplasm
  • Genetic Heterogeneity
  • Genomics*
  • High-Throughput Nucleotide Sequencing
  • Humans
  • Molecular Targeted Therapy
  • Mutation, Missense
  • Neoplasms / drug therapy*
  • Neoplasms / genetics*
  • Precision Medicine*
  • Sequence Analysis, DNA