Applications of Immunogenomics to Cancer

Cell. 2017 Feb 9;168(4):600-612. doi: 10.1016/j.cell.2017.01.014.


Cancer immunogenomics originally was framed by research supporting the hypothesis that cancer mutations generated novel peptides seen as "non-self" by the immune system. The search for these "neoantigens" has been facilitated by the combination of new sequencing technologies, specialized computational analyses, and HLA binding predictions that evaluate somatic alterations in a cancer genome and interpret their ability to produce an immune-stimulatory peptide. The resulting information can characterize a tumor's neoantigen load, its cadre of infiltrating immune cell types, the T or B cell receptor repertoire, and direct the design of a personalized therapeutic.

Publication types

  • Review
  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Antigens, Neoplasm / immunology*
  • Cancer Vaccines / immunology
  • Genome, Human
  • HLA Antigens / immunology
  • Humans
  • Immunogenetics
  • Lymphocytes, Tumor-Infiltrating / immunology
  • Mutation
  • Neoplasms / genetics*
  • Neoplasms / immunology*
  • Sequence Analysis, Protein


  • Antigens, Neoplasm
  • Cancer Vaccines
  • HLA Antigens