Synthetic (polymer) biology (membrane): functionalization of polymer scaffolds for membrane proteins

Curr Opin Biotechnol. 2017 Aug;46:51-56. doi: 10.1016/j.copbio.2016.10.012. Epub 2017 Feb 7.

Abstract

A plethora of polymer-based scaffolds have been designed to facilitate biochemical and biophysical investigation of membrane proteins, with a common goal to stabilize and present them in a functional format. In this review, an up-to-date account of such polymer-based supports and incorporation methodologies are presented. Furthermore, conceptual and imminent technological advances, with associated technical challenges are proposed.

Publication types

  • Review

MeSH terms

  • Humans
  • Membrane Proteins / chemistry*
  • Membranes, Artificial*
  • Polymers / chemistry*
  • Synthetic Biology / methods*

Substances

  • Membrane Proteins
  • Membranes, Artificial
  • Polymers